水飞蓟素固体脂质纳米粒的制备及体外释放研究

Study on Preparation of Silymarin Solid Lipid Nanoparicles and in vitro Release

以单硬脂酸甘油酯为脂质材料,豆磷脂与泊洛沙姆188为乳化剂,水飞蓟素为试验药材,采用乳化-超声分散法制备SM-SLN胶体溶液,对其粒径、形态、包封率和载药量及体外释放进行研究,并对其稳定性进行研究。结果表明:所制得的纳米粒外观形态圆整,平均粒径为150.6nm,平均包封率为85.3%。乳化-超声分散法适用于SM-SLN的制备,其制剂包封率高,粒度分布较均匀,具有较好的稳定性。

Taking monostearin lipid as material, soybean lecithin and poloxamer 188 as emulsifier, silymarin as a model drug, SM-SLN were prepared by the emulsification ultrasonic dispersion method. The particle size, morphology, encapsulation efficiency, drug loading, in vitro release and stability were studied. The results showed that morphology of SM-SLN was round and smooth, and the average particle size was 150. 6 nm and encapsulation efficiency 85.3%. Emulsification ultrasonic dispersion method was suitable for SM-SLN preparation, with high encapsulation efficiency, uniform particle size distribution and better stability.