高原地区胎盘VEGF在胎儿生长受限和巨大儿中的表达及意义

Expression of plateau area placenta vascular endothelial growth factor iIn fetal growth restriction And Great children and its significance

目的血管内皮生长因子(VEGF)是一种对血管内皮细胞有特异高效的促有丝分裂因子,通过检测血管内皮生长因子在胎盘母面和子面的水平,探索胎儿生长受限和巨大儿的发病因素和发生的机制。方法随机选择2010年1月至2011年2月在青海省妇女儿童医院足月分娩的足月小样儿(体重<2 500g的新生儿)50例产妇为宫内发育受限组,选择同期分娩体重≥4 000g新生儿50例产妇为巨大儿组;采用免疫组化链霉菌抗生物素蛋白-过氧化酶连接法(SP法)检测巨大儿(对照组)和胎儿生长受限患者(IUGR组)胎盘组织中VEGF的表达;巨大儿和IUGR组均为初产妇,两组孕妇年龄、孕周及体质量差异无显著性。结果胎儿生长受限患者胎盘组织中VEGF阳性表达率低于巨大儿组,两者差异有统计学意义(P<0.05)。结论 IUGR患者胎盘VEGF水平下降,可能是胎儿生长受限发病机理中的一个重要因素。

Objective Vascular endothelial growth factor is a vascular endothelial cell - specific and efficient mitogenic factor, by vascular endothelial growth factor in placenta parent surface and sub - surface level, to explore fetal growth re- striction and a huge children＇s risk factors and the mechanisms. Methods Randomly selected from January 2010 to Feb- mary 2011 in our hospital term delivery of full -term small for gestational age （body weight 〈 2500g neonates） 50 cases of maternal intrauterine growth restriction group, select the new year birth weight ≥4000g children 50 cases of maternal child for the great group ; Immunohistochemical streptavidin - biotin - peroxidase method （ SP method） to detect a huge children （control group ） and patients with fetal growth restriction （IUGR group ） placental tissue VEGF expression; Great children and the IUGR group were primipara, two groups of maternal age, gestational age and body mass difference was not statistically significant. Results Fetal growth restriction in placental tissue in patients with VEGF positive ex- pression rate of children less than a huge group, the difference was statistically significant （P 〈 0. 05 ）. Conclusions VEGF decreased levels in IUGR patients, it may be an important factor of fetal growth restriction pathogenesis.