黄连温胆汤对代谢综合征大鼠炎性因子及血管粘附因子的影响

The Effect of Huanglian Wendan Decoction on Inflammatory Factors and VCAM-1 of Metabolic Syndrome Rats

目的:研究黄连温胆汤对代谢综合征大鼠炎性因子及血管粘附因子等指标的影响,探讨其作用机制。方法:通过膳食喂养建立MS大鼠模型,将成模的MS大鼠随机分成模型组,中药高、低剂量组,格华止组,灌胃4周后,检测主动脉HE染色、炎性因子及血管粘附因子。结果:与空白组比较,模型组血清ADPN、IL-6具有统计学意义(P<0.05),中药高、低剂量组及格华止组血清ADPN、IL-6水平与模型组相比,有统计学意义(P<0.05),中药高、低剂量组及格华止组大鼠血管VCAM-1表达均明显降低(P<0.05)。结论:黄连温胆汤可调控MS大鼠血清ADPN、IL-6水平,且可抑制VCAM-1过度表达。

Objective：To study the effects of Huanglian Wendan decoction on inflammatory factors and VCAM - 1 of rats with metabolic syndrome induced by dietary, and analyse the mechanism. Method： Male SD rats were fed by high ener- getic diet for 20 weeks to copy the model of metabolic syndrome. 37 model rats with metabolic syndrome were randomly divided into 4 groups ： model group, herb high - dose group, herb low - dose group and control group, and each group was lavaged with drugs for 4 weeks to detect H - E staining of aorta, inflammatory factors and VCAM - 1 . Result ： Com- pared with the normal group, the level of IL - 6 and ADPN in model group had a statistical significance （ P 〈 0.05 ）. Contrast to model group, the serum level of IL - 6 and ADPN in herb high - dose group, low - dose group and control group had a statistical significance （P 〈 0.05 ）. The expression of VCAM - 1 of rats in herb high - dose group, low - dose group and control group decreased obviously which had a statistical significance （ P 〈 0.05 ）. Conclusion ： Huangli- an Wendan decoction can regulate the serum level of IL- 6 and ADPN and repress the over- expression of VCAM -1.