甲硝唑芬布芬胶囊中甲硝唑含量的电化学研究

Electrochemistry Researchon Metronidazole and Fenbufen Capsules Metronidazole Content

用预镀铋膜玻碳电极，采用差分脉冲溶出伏安法测定甲硝唑芬布芬胶囊中甲硝唑的含量。预镀铋膜玻碳电极提高了甲硝唑的电化学响应，出峰好，灵敏度高，且具有较好的稳定性。实验结果表明：在支持电解质O．60mol／L的KCl和PBS（pH=7．00）中于电沉积电位为-250mV下搅拌富集120s后，可获一灵敏的阳极溶出峰，利用此法测定甲硝唑的检出限D：3．6×10-7mol／L，线性范围为（0．17～1．03）×10-3mg／mL，线性方程I=0．0891c＋4×10-5，相关系数r=0．9987，相对标准偏差RSD=4．00％，样品B的加标回收率为94．18％～102．27％，结果令人满意。

The bismuth film electrode in differential pulse stripping analysis for the determintation of metronidazole in galculus boris and metronidazole capsules was proposed. The hisnmth film electrode , compared with at bare GOE , enhanced significantly, had high sensitive and displayed well- defined peak. In a supporting solution of 0.60 mol/L KCl and PBS （pH =7.00）, the concentration potential of the metronidazole in - 250 mV for 120 s enhanced anodic stripping peak current. The experiment results showed a high response, a good linear range （between 0.17 mg / mL - 1.03 × 10.3 mg / mL）, a good precision （RSD = 4.00%） and a low detection limit 3.6 × 10-7 mol / L. Under optimum conditions, The equation of linear regression is 1 = 0.0891c ＋ 0.00004, correlation coefficient r = 0.9987. The recovery range from 94.18% - 102.27%, The result is satisfactory.