帕金森病患者膀胱过动症状评估

Assessment of concomitant overactive bladder symptoms in Parkinson disease

目的分析PD患者膀胱过动症状(OABS)的患病率、影响因素以及OABS对PD患者生活质量(health related quality of life,HRQL)的影响。方法运用膀胱过度活动症问卷(overactive bladder question-naire,OAB-q)、统一帕金森病评分量表(UPDRS)对115例PD患者进行评估。结果 PD患者OABS患病率47.0%。PD组OABSS得分明显高于对照组(P=0.000);PD组的生活质量得分均低于对照组。年龄及帕金森病严重程度与PD患者OABS严重程度呈正相关。OAB组HRQL得分较非OAB组低(P=0.003)。结论 OABS是PD患者中常见的非运动症状之一,OABS严重影响PD患者生活质量,年龄增长和PD病情恶化可增加OABS的严重程度。

Objective To analyze the prevalence and impact factors of overactive bladder symptoms（OABS） and the OABS influence on health related quality of life（HRQL） in patients with Parkinson disease（PD）.Methods The overactive bladder questionnaire（OAB-q） and unified Parkinson disease rating scale（UPDRS） were used to evaluate 115 patients with idiopathic PD.The results were taken from PD patients and compared with those of 123 control subjects.Results The prevalence of OABS in PD patients was 47.0%.Compared with the control subjects,PD patients had higher overactive bladder symptom severity（OABSS） score（P=0.000） and lower HRQL score.PD patients with OABS were lower in HRQL score than PD patients without OABS（P=0.003）.The age and severity of PD were the impact factors of OABS.Conclusions OABS is a kind of common symptom in PD patients,which influenced the HRQL of PD patients seriously.OABS will be worse when the PD patients are older and PD is aggravated.