冠状动脉粥样硬化性心脏病冠脉循环建模与仿真

Modeling and Simulation for the Coronary Circulation of Ischemic Heart Disease

冠状动脉粥样硬化性心脏病发病率和死亡率都很高,对其进行建模与仿真有重要的医学意义.在左心循环系统的血流动力学仿真建模的基础上,结合冠状动脉粥样硬化的病理学特点及临床数据,建立描述心血管冠状循环与系统循环之间血液动力学关系的模拟电路模型,并运用Matlab/Simulink对模型进行仿真,模拟冠状动脉粥样硬化性心脏病病理状态下的冠脉循环血流情况.模型通过修改参数,能模拟不同个体生理情况特征,仿真不同程度的冠状动脉狭窄的血流情况.仿真波形与动物实验结果相吻合,通过对血流储备分数(FFRmyo)的计算,也进一步验证仿真结果的正确性.

It is acknowledged that the coronary atherosclerotic heart disease is the most widespread kind of heart disease. The researches on the field of modeling and simulation for the coronary circulation of CHD have great medicinal significance. Based on previous work on some simulation experiments of arterial system on left heart-arterial interaction coincide with the pathological characteristics and clinical parameters of CHD,a dynamic simulation model was built for the system of coronary circulation on CHD by using Mat- lab/Simulink, characterized the hemodynamic relations between the coronary circulation and systemic circulation. This model has been digitally simulated for coronary flow of different physiology and different degree of coronary artery stenosis of CHD by changing the parameter, the results were consistent with clinical observations of animal experimentation. The correctness of the results are further verified from the calculation of the conclusion of FFRmyo.