莫匹罗星软膏治疗中心静脉置管后导管出口感染的研究

Effect of Mupirocin Ointment on Central Venous Catheter-Related Exit-site Infection

目的:观察莫匹罗星软膏外用治疗导管相关性出口感染的疗效,探索治疗、护理中心静脉置管后导管出口感染的新方法。方法:根据筛选标准筛选出中心静脉置管术后导管出口感染病例162例,并随机分为实验组和对照组,其中实验组82例,采用普通换药后加莫匹罗星软膏外用治疗,每日一次;对照组80例,仅用普通换药方法治疗,每日一次。每日换药时观察治疗效果。结果:莫匹罗星+常规换药治疗导管出口感染有效率高于常规换药治疗。χ2检验比较两组治疗方法疗效差异,P<0.05,差异有统计学意义;t检验比较两组治疗疗程差异,P<0.01,实验组疗程短于对照组,平均疗程分别为3.56±0.135天和4.45±0.165天。

Objective： To study the effect of Mupirocin Ointment on Central Venous Catheter-Related exit-site infection and investigate the new method of nursing the exit-site infection. Methods： 162 cases were selected due to the screening standards, and then divided into two groups randomly（experimental group, n= 82;control group, n = 80）. The experimental group were treated by Mupirocin Ointment after ordinary dressing change while the control group accepted the ordinary dressing change. All were done once per day, and the effects were observed when nursing care. Results： Compared with the control groups, we observed distinct effects on experimental group . Chi-square test shows evident difference between the effects of the two groups （P〈0. 05）. T-test shows that the mean course of treatments were significant difference between two groups（P〈0.01）. And the mean courses were 3. 56±0. 135d and 4. 45±0. 165d. Key words Mupirocin; central venous catheter; exit-site infection