步行锻炼对化学治疗的结肠癌患者癌因性疲乏的影响

Effects of Walking Exercise on Cancer-related Fatigue of Colon Cancer Patients undergoing Chemotherapy

目的探讨步行锻炼对接受化学治疗的结肠癌患者癌因性疲乏的影响。方法便利抽样法选取2009年1月至2010年6月在解放军总医院肿瘤中心接受术后辅助化学治疗的58例结肠癌患者为研究对象,按随机数字表法将其分成对照组和观察组,每组29例。对照组患者给予常规护理,观察组患者在常规护理的基础上进行步行锻炼。在研究第1天(化疗前,基线水平)、第5天(第1周期化疗)、第19天(第2周期化疗)后,比较两组患者重度疲乏率和简明疲乏量表(brief fatigue inventory,BFI)评分。结果观察组患者较对照组患者重度疲乏发生率低(第5天,6.9%vs 10.3%,P<0.05;第19天,10.3%vs20.7%,P<0.05),BFI评分低,差异有统计学意义[BFI,第5天,(4.38±1.05)vs(5.68±1.07),P<0.05;第19天,(4.91±1.14)vs(6.24±1.20),P<0.05])。结论步行锻炼可以减轻化疗患者的癌因性疲乏。

Objective To investigate the effects of walking exercise on cancer-related fatigue of colon cancer patients undergoing chemotherapy. Methods From January 2009 to June 2010,58 colon cancer patients undergoing adjuvant chemotherapy in our department were selected using convenience sampling and randomly divided into control group（n= 29） and observation group（n= 29）. Patients in the control group received general nursing care, whereas patients in the observation group received walking exercise based on the general nursing care. Comparisons were conducted on the scores of brief fatigue inventory （BFI）and rates of severe cancer-related fatigue on day l（before chemotherapy,baseline level）,day 5（1 cycle of chemotherapy） and day 19（2 cycles of chemotherapy） between the two groups. Results Patients in the observation group had lower incidence of severe cancer-related fatigue （on day 5,6.9 % vs 10.3 %, P〈0.05;on day 19,10.3% vs 20.7%,P〈0.05） and lower levels of fatigue intensity （BFI,on day 5,4.38±1.05 vs 5.68±1.07,P〈0. 05;on day 19,4. 91±1. 14 vs 6. 24±1. 20,P〈0. 05） than those in control group, the differences were statistically significant. Conclusion Walking exercise can effectively relieve cancer-related fatigue of colon cancer patients undergoing chemotherapy.