上海市卢湾区甲型H1N1流感与季节性流感流行特征比较分析

Comparison of epidemiological characteristics of type AH1N1 influenza and seasonal influenza in Luwan District,Shanghai

目的比较甲型H1N1流感与季节性流感流行特征,为制定干预措施提供科学依据。方法对卢湾区2009年7月～2011年11月流感监测病例进行分析,并于2011年10月对卢湾区200名居民进行流感HI抗体检测。结果 2009年,AH1N1阳性率最高,为30%;2010年,AH3、BV阳性率较高,分别为13%和12%;2011年,AH1N1、BV阳性率较高,分别为12%和11%。AH1N1流行季节主要为冬季,AH3主要为夏季,BV主要为春季。全人群BY和AH1抗体滴度较高,分别为1∶918和1∶897,BV、AH3和AH1N1抗体滴度较低,分别为1∶625,1∶599和1∶120。AH1N1全人群抗体水平低于季节性流感。结论应继续加强流感疫苗接种工作,建议流感疫苗组分应继续包括AH3、AH1N1、BV毒株组分。

Objective To compare the epidemicological characteristics of type AH1 N1 influenza and seasonal influenza and to provide scientific basis on interventions. Methods The pathogen surveillance data of flu surveillance sentinel hospital of Luwan District from Jnly 2009 to November 2011 was collected. We calculated 519 surveillance cases by age, year, month and week. In October 2011, we selected a probability sample of 200 residents of Luwan District. For each subject we measured HI antibody of influenza. Results In 2009, type AH1 N1 accounted for the highest positive rate of 30%. In 2010, type AH3 accounted for the highest positive rate of 13%, followed by type BV with positive rate as 12%. In 2011, type AH1N1 accounted for the highest positive rate of 12%, followed by type BV with positive rate as 11%. Type AHIN1 became epidemic mainly in winter, type AH3 became epidemic mainly in summer, type BV mainly in spring. The whole population had relatively high antibody levels of type BY and AH1 with their geometric mean titer of antibody accounted for 1 ： 918 and 1 ： 897 respectively, while the antibody levels of type BV, AH3 and AH1N1 were relatively low with their geometric mean titer of antibody accounting for 1 ： 625, 1 ： 599 and 1 ： 120 respectively. The antibody level of type AH1 N1 was significantly lower than that of other subtypes of influenza for the whole population. Conclusions Vaccine components should continue including type AH3, AH1 N1 and BV strain components.