摘要
microRNAs(miRNAs)是一类长约22个核苷酸(nucleotide,nt)的非编码小分子RNAs,通过与靶基因的特异序列完全或不完全互补结合,来调控靶基因表达,参与生物体生长、发育、疾病发生(诸如炎症、肿瘤)等几乎所有的生理病理过程。炎症是机体对损伤因子所发生的复杂的防御反应,可以改变癌基因和抑癌基因(包括蛋白编码基因和非编码小分子RNA基因)的表达和转化,促进细胞的恶性转变。深入理解microRNAs及炎症反应在肿瘤发生发展过程中的单独作用及作用交集,将为肿瘤的早期预防和治疗提供新的突破点。
microRNAs （miRNAs） are a class of small non-coding RNAs of about 22 nucleotide （nt） in the length that play an important role in regulating gene expression through complete or incomplete matching with the 3 ＇ -UTR of target mRNAs. They are involved in almost all of the physiological and pathological processes, such as growth, development and disease occurrence, such as inflammation and cancer. Inflammation is the complex defense response of body to injury factors, which can change the expression and transformation of the oncogene and anti-oncogene and then promote malignant transformation of cells. To explore the single role and role of intersection that microRNAs and inflammation in tumorigenesis will provide us with new breakthrough for cancer prevention and early treatment.
出处
《中华疾病控制杂志》
CAS
北大核心
2012年第9期804-808,共5页
Chinese Journal of Disease Control & Prevention
基金
国家自然科学基金(30771845
81172766)
关键词
微RNA
炎症
肿瘤
MicroRNAs
Inflammation
Neoplasms
