胶质瘤发病风险与手机使用的系统评价

Glioma Risk in Relation to Mobile Phone Use:a Systematic Review

目的评价胶质瘤与手机使用危险性的联系。方法计算机检索MEDLINE、Web of Science、EMBASE、EBSCO、Cochrane Library、ScienceDirect数据库;收集胶质瘤与手机使用相关的病例对照研究文献,检索时间2000-2011年,采用RevMan5.1进行Meta分析。结果 8篇病例对照研究文献纳入,规律使用手机未见有胶质瘤危险性增高;而长期使用手机10年以上者与胶质瘤发生存在联系,OR=1.24（95%CI=1.10~1.40）,长期同侧使用手机发生胶质瘤危险性增加58%,OR=1.58（95%CI=1.30~1.94）。结论规律使用手机并不增高胶质瘤的发生风险,长期频繁使用手机可能增加胶质瘤发生的风险,但分析中的偏倚与混杂因子可能影响因果关系的解释。

Objective To evaluate the association between glioma risk and mobile phone use. Methods The electron- ic databases including MEDLINE, Web of Science, EMBASE, EBSCO, Cochrane Library and ScienceDirect were searched from 2000 to 2011 to collect the case- control studies on association between glioma and mobile phone use. Then Meta- analysis was conducted by RevMan 5.1. Results A total of 8 case - control studies were included. Analysis findings did not indicate an in- creased risk of glioma in relation to regular use of mobile phones. A somewhat increased risk was found for long - term use of mo- bile phones for 10 years or more （OR = 1.24, 95 % CI = 1.10-- 1.40）. There were suggestions of an increased risk of glioma for long- term ipsilateral exposures （OR = 1.58, 95 % CI = 1.30 -- 1.94）. Conclusions No increase in risk of glioma is ob- served in relation to regular use of mobile phones. There are suggestions of an increased risk of glioma with long - term heavy use of mobile phone, but biases and confounding factors may prevent a causal interpretation.