应用ROC曲线评价AFP、AFU、5’-NT在原发性肝癌诊断中的意义

Assessment on the Value of AFP,AFU and 5'-NT in Diagnosis of Primary Hepatic Carcinoma by ROC Curve

目的探讨α-L-岩藻糖苷酶(AFU)、甲胎蛋白(AFP)、5’-核苷酸酶(5’-NT)检测对原发性肝癌(PHC)患者的诊断价值。方法测定125例肝癌患者及50例体检者作为对照组,应用ROC曲线进行比较与分析。结果 AFU、AFP和5’-NT检测指标在两组资料间比较差异均有统计学意义。AFP、AFU和5’-NT三种指标单独检测时,ROC曲线下面积分别为0.707、0.803、0.817。三项标志物单项检测PHC的敏感性分别为0.68、0.81、0.80,联合检测AFP和AFU或5’-NT可使PHC检出率提高至0.888和0.872,三项标志物联合检测PHC的检出率高达0.92。结论通过ROC曲线评价,联合检测AFP、AFU和5’-NT三种指标可以提高对原发性肝癌(PHC)患者的诊断价值。

Objective To explore the diagnostic value of a - fetoprotein （AFP）, AFU （a- L - fucosidase）, 5＇ - NT （5＇ -nucleotidase） and their combinations for primary hepatic carcinoma （PHC）. Methods Serum AFP, AFU and 5＇ - NT were detected in 125 patients with PHC （PHC group） and 50 healthy people （control group）. The test results were compared and analyzed by ROC curve. Results The levels of AFP, AFU and 5＇ - NT were significantly different between the two groups （P〈0.05）. The areas under ROC curves of AFP, AFU and 5＇ - NT of PHC patients were 0. 707, 0. 803 and 0. 817 re- spectively. The sensitivity of AFP , AFU and 5＇ - NT for PHC diagnosis was 0.68,0.81 and 0.80 respectively. Combination of AFP and AFU or 5＇ - NT could increase the sensitivity to 0. 888 and 0. 872, and combined detection of AFP, AFU and 5＇ - NT could raise the sensitivity to 0.92. Conclusions Roc curve suggests that the combined detection of AFP, AFU and 5＇ - NT is superior to any single index in PHC diagnosis. It can greatly increase the detection of PHC.