肝素生理盐水用于D-二聚体升高老年患者中心静脉测压研究

Heparin and normal saline solutions for measurement of central venous pressure in elderly patients with elevated D-dimer levels

目的解决D-二聚体升高老年患者行中心静脉测压后易出现深静脉导管堵塞的问题。方法将74例D-二聚体升高老年患者分为对照组34例、观察组40例,对照组采用生理盐水行中心静脉测压,观察组采用125U/mL肝素生理盐水行中心静脉测压。结果观察组堵管发生率低于对照组,计划拔管的比例高于对照组,置管时间长于对照组(均P<0.01)。观察组未发生出血征象,APTT值测压前后比较,差异无统计学意义(P>0.05)。结论采用125U/mL肝素生理盐水对D-二聚体升高老年患者进行中心静脉测压,可降低测压后深静脉导管堵塞发生率,有利于静脉途径的治疗与护理。

Objective To solve the problem of catheter blockage developed after measurement of central venous pressure（CVI） in el-derly patients with elevated D-dimer levels. Methods Seventy-four elderly patients with elevated D-dimer levels were divided into a control group（n=34） and an observation group（n=40） receiving either normal saline or 125 U/mL of heparin and normal saline solutions for CVI measurement. Results Compared with the control group,the observation group achieved less blockage of catheters,higher planned extubation,and longer indwelling time of catheters（P〈0.01 for all）.None of the patients in the observation group developed hemorrhage,and the value of APTT had no statistical difference before and after CVI measurement（P〉0.05）. Conclusion Measurement of central venous pressure in elderly patients with elevated D-dimer levels by using 125 U/mL of heparin and normal saline solutions,can reduce blockage of catheters.