摘要
放射治疗为头颈部肿瘤的主要治疗手段，由于头颈部解剖关系复杂及射线的非选择性，辐射常可直接损伤唾液腺，导致口干燥症的发生。射线亦可间接引起组织基质纤维化及营养血管闭锁，加剧病情恶化。目前利用调强放射治疗、药物及颌下腺移位术等，均取得一定成效。近年，天然植物提取物逐渐成为关注焦点，细胞、基因等方面的探究亦逐渐深入，现就放射性口干燥症防治的研究进展综述如下。
出处
《广东医学》
CAS
CSCD
北大核心
2012年第17期2691-2693,共3页
Guangdong Medical Journal
参考文献20
-
1PENG Z, XU Z W, WEN W S, et al. Tea polyphenols protect against irradiation - induced injury in submandibular glands' ceils : a preliminary study [ J ]. Arch Oral Biol, 2011, 56 ( 8 ) : 738 - 743.
-
2QIONG L, JUN L, JUN Y, et al. The effect of Laminaria japonica polysaccharides on the recovery of the male rat reproductive system and mating function damaged by multiple mini - doses of ionizing ra- diations[J]. Environ Toxicol Pharmacol, 2011, 31(2): 286-294.
-
3梁杰珍,孙文忠,徐志文,曾曼丽,陈美球.海带多糖对放疗后颌下腺细胞凋亡的影响[J].重庆医学,2011,40(15):1466-1467. 被引量：5
-
4NANDURI L S, MAIMETS M, PRINGLE S A, et al. Regenera- tion of irradiated salivary glands with stem cell marker expressing cells[J]. Radiother Oncol, 2011, 99(3): 367-372.
-
5COPPES R P, STOKMAN M A. Stem cells and the repair of radia- tion- induced salivary gland damage [J]. Oral Dis, 2011, 17 (2) : 143 -153.
-
6LIN C Y, LEE B S, LIAO C C, et al. Transdifferentiation of bone marrow stem cells into acinar ceils using a double chamber system [J]. J Formos Med Assoc, 2007, 106(1) : 1 -7.
-
7LIN C Y, CHANG F H, CHEN C Y, et al. Cell therapy for salivary gland regeneration[J]. J Dent Res, 2011,90(3) : 341 -346.
-
8BURT R K, LOH Y, PEARCE W, et al. Clinical applications of blood- derived and marrow -derived stem cells for nonmalignant diseases[J]. JAMA, 2008, 299(8): 925 -936.
-
9SUMITA Y, LIU Y, KHALILI S, et al. Bone marrow -derived cells rescue salivary gland function in mice with head and neck ir- radiation [ J]. Int J Biochem Cell B iol, 2011, 43 ( 1 ) : 80 - 87.
-
10TRAN S D, SUMITA Y, KHALILI S. Bone marrow- derivedcells: a potential approach for the treatment of xerostomia[ J]. Int J Biochem Cell Biol, 2011, 43 ( 1 ) : 5 - 9.
二级参考文献15
-
1邓长江,朱希强,郭学平.海带多糖药理作用的研究进展[J].食品与药品,2006,8(04A):30-32. 被引量：11
-
2钟原,江跃全.心肌细胞凋亡及其相关基因[J].检验医学与临床,2007,4(3):202-203. 被引量：2
-
3刘杨,亢登峰,王英元.大鼠脊髓损伤后IGF-1和Bcl-2表达变化的免疫组织化学研究[J].中西医结合心脑血管病杂志,2007,5(2):134-136. 被引量：12
-
4秦俭（综述）,王仁生（审校）.唾液腺放射性损伤及其防护[J].国际肿瘤学杂志,2007,34(4):258-261. 被引量：5
-
5崔巍,王硕仁,朱陵群,等.平均光密度值分析法和阳性染色面积分析法在免疫组化图像分析中的对比研究[C]//中华中医药学会内科分会.中医内科学科建设研讨会论文汇编.北京,2008:148-151.
-
6Rades D,Fehlauer F,Wroblesky J,et al.Prognostic factors in head-and-neck cancer patients treated with surgery followed by intensity-modulated radiotherapy (IMRT),3D-conformal radiotherapy,or conventional radiotherapy[J].Oral Oncol,2007,43(6):535-543.
-
7Konings AW,Coppes RP,Vissink A.On the mechanism of salivary gland radiosensitivity[J].Int J Radiat Oncol Biol Phys,2005,62(4):1187-1194.
-
8郭锐,刘艳华.海带多糖的保健功效及其在职业防护中的应用展望[J].国际医药卫生导报,2008,14(2):118-121. 被引量：3
-
9罗小宁,黄晓明.放射性口干症[J].国际耳鼻咽喉头颈外科杂志,2009,33(1):46-48. 被引量：1
-
10霍文艳,彦兴,韩培彦.涎腺放射损伤的发病机制与治疗[J].中华老年口腔医学杂志,2009,7(2):106-109. 被引量：8
共引文献4
-
1曾曼丽,孙文忠,徐志文,魏媛媛,郑实兴.海带多糖对人鼻咽癌细胞及其裸鼠移植瘤的抑制作用[J].中国肿瘤临床,2012,29(10):634-638. 被引量：2
-
2魏媛媛,徐志文,孙文忠,郑实兴,袁东杰.海带多糖对放疗后颌下腺血管的影响[J].中华中医药杂志,2014,29(4):1225-1228. 被引量：2
-
3张悦,王静,李铁军.海带多糖抗肿瘤活性研究进展[J].药学实践杂志,2016,34(5):393-395. 被引量：5
-
4张思琴,敖翩,陈少勇,柴溶,王绍军,韦力,徐杨,陈晨.海带多糖通过促进Sirt3/MnSOD表达来改善受照射后小鼠的下颌下腺损伤[J].辐射防护,2021,41(3):264-270.
同被引文献26
-
1Pringle S,Van Os R, Coppes RP. Concise review: adult salivary gland stem cells and a potential therapy for xerostomia[J]. Stem Cells, 2013,31:613-619.
-
2Grundmann O, Mitchell GC, Limesand KH. Sensitivity of salivary glands to radiation: from animal models to therapies[J]. J Dent Res, 2009,88:894-903.
-
3Li Y,Taylor JM,Ten Haken RK,et al.The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radi- ation therapy[J].Int J Radiat Oncol Biol Phys,2007,67: 660-669.
-
4Medina VA,Prestifilippo JP,Croei M ,et al. Histamine prevents func- tional and morphological alterations of submandibular glands in- duced by ionising radiation [J]. Int J Radiat Biol,2011,87:284-292.
-
5Tatsuishi Y, Hiyota M, Kishi T,et al. Human salivary gland stem/pro- genitor cells remain dormant even after irradiation[J]. Int J Mol Med, 2009,24:361-366.
-
6Lombaert IM,Knox SM,Hoffman MP. Salivary gland progenitor cell biology provides a rationale for therapeutic salivary gland regenera- tion[J].Oral Dis,2011,17:445-449.
-
7Neumann Y, David R, Stiubea-Cohen R,et al.Long-term cryop- reservation model of rat salivary gland stem cells for future therapy in irradiated head and neck cancer patients [J].Tissue Eng:Part C Methods,2012,18:710-718.
-
8Lombaert IM, Brunsting JF, Wierenga PK ,et al.Rescue of salivary gland function after stem cell transplantation in irradiated glands[J]. PLoS One, 2008,3:e2063.
-
9Feng J, van der Zwaag M, Stokman MA,et al.lsolation and character- ization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation[J]. Radiother Oncol,2009, 92:466-471.
-
10Gorjup E, Danner S, Rotter N,et al. Glandular tissue from human pancreas and salivary gland yields similar stem cell populations[J].Eur J Cell Biol,2009,88:409-421.
-
1陈秀杰,曾宪玲,黎锦燕,梁记清,廖日娣.颌下腺移位术防治鼻咽癌放疗后口干燥症的护理36例[J].中国实用护理杂志（下旬版）,2005,21(5):35-36. 被引量：2
-
2项认好,区爱武,梁晓敏,黎穗.颌下腺移位术的手术配合[J].南方护理学报,2004,11(6):29-30. 被引量：7
-
3唐美香.唇腺活检患者的护理[J].中国实用医药,2009,4(23):190-191.
-
4马东洋,邱蔚六,张陈平.放射性口干燥症的预防与治疗现状[J].中华口腔医学杂志,2010,45(2):121-123.
-
5周霓(综述),徐志文(审校).鼻咽癌放疗后口干燥症的发生机制及防治研究进展[J].中国医学文摘（肿瘤学）,2007,21(3):258-259.
-
6王中和.呼吁建立我国的口干燥症分级标准[J].中华口腔医学杂志,2010,45(8):449-452. 被引量：17
-
7赵新涛.人性化护理管理在防范护患纠纷中的作用[J].中医药管理杂志,2009,17(7):649-650. 被引量：11
-
8黄倜,张华东,王振兴,王梓淞,李晶.干燥综合征口干燥症的中医外治进展[J].风湿病与关节炎,2012,1(4):69-71. 被引量：4
-
9薛艳.挤压伤的急救护理[J].郧阳医学院学报,2009,28(6):637-638.
-
10杜德顺.口干、口干燥症及其治疗进展[J].中华临床医师杂志（电子版）,2008,2(9):8-11. 被引量：25
