老年急性脑梗死患者血清高迁移率蛋白-1和中性粒细胞激活肽-78的变化

Changes of Serum HMGB1 and ENA-78 Levels in Elderly Patients with Cerebral Ischemic Stroke

目的:探讨老年急性脑梗死患者血清高迁移率蛋白-1(HMGB1)和中性粒细胞激活肽-78(ENA-78)的动态变化。方法:采用酶联免疫吸附法(ELISA)测定112例老年脑梗死患者(梗死组)与100例老年健康对照者(对照组)血清HMGB1与ENA-78水平。结果:梗死组不同病情程度患者的HMGB1与ENA-78水平均显著高于对照组(P均<0.01),并且随着病情程度的加重而逐渐升高。预后不良患者的血清HMGB1与ENA-78水平显著高于预后良好患者及对照组(P<0.01)。梗死组血清HMGB1水平与ENA-78水平呈显著正相关(r=0.62,P<0.01)。结论:血清HMGB1与ENA-78水平监测对于判断老年急性脑梗死患者病情严重程度及评估预后有重要意义。

Objective：To investigate the dynamic changes of serum high mobility group box-1（HMGB1） and epithelial neutrophil-l activating peptide-78（ENA-78） levels in elderly patients with cerebral ischemic stroke.Methods：Serum HMGB1 and ENA-78 levels were measured by enzyme-linked immunosorbent assay（ELISA） in 112 elderly patients with cerebral ischemic stroke（stoke group） and 100 health contrds（control group）.Results：Serum HMGB1 and ENA-78 levels in the stroke group were significantly higher than those in the control group（P〈0.01,respectively）.With the severity of cerebral ischemic stroke,the serum HMGB1 and ENA-78 levels increased.Serum HMGB1 and ENA-78 levels in the poor outcome patients were significantly higher than those in the satisfied outcome patients and the control group（P〈0.01,respectively）.Serum HMGB1 level were significantly relevant to serum ENA-78 levels（r=0.62,P〈0.01）.Conclusion：The changes in serum HMGB1 and ENA-78 levels may be associated with severity of strokes and could be used as markers for outcomes of cerebral ischemic stroke in elderly patients.