慢性疲劳综合征患儿的智力结构评估及弥散张量成像研究

Evaluation of Intelligence Structure and Diffusion Tensor Imaging MRI in Children with Chronic Fatigue Syndrome

目的:研究慢性疲劳综合征(CFS)患儿与正常对照儿童智力结构的差异,并且采用弥散张量成像(DTI)技术观察2者白质纤维的差异。方法:CFS患儿27例为CFS组,27例与CFS组基本匹配的健康志愿者为对照组。所有被试者首先进行韦氏智力测验(C-WISC),计算言语智商(VIQ)、操作智商(PIQ)、总智商(FIQ)、记忆/不分心(M/C)因子等,其后行DTI扫描,采用基于像素的分析方法比较2组的部分各项异性(FA)值。结果:CFS组FIQ、VIQ和PIQ都在正常水平,与对照组差异无统计学意义,CFS组M/C因子低于对照组(P<0.0083)。CFS组右侧胼周额部深部白质(PCF)及左侧视放射(OR)FA值显著低于对照组。结论:CFS患儿存在短时记忆以及注意缺陷,PCF及OR功能缺陷可能与其智力结构缺陷有关。

Objective： To assess the structure of intelligence and explore the changes of white mater（WM） in children with chronic fatigue syndrome（CFS） using diffusion tensor imaging（DTI） examination.Methods： Twenty-seven CFS children（CFS group） and 27 healthy controls（control group） were recruited.Firstly,intelligence tests were performed using Wechsler Intelligence Scale-Revised China（C-WISC） in the CFS patients and controls.The full intelligence quotient（FIQ）,verbal IQ（VIQ）,performance IQ（PIQ） and memory/caution（M/C） factor were measured.After intelligence tests,DTI scans were performed.Voxel-wise statistical analysis of the fractional anisotropy（FA） data was carried out to investigate differences between 2 groups.Results： The FIQ,VIQ and PIQ in the CFS group were within the normal range and did not significantly differ from those in the control group.The M/C factor was statistically lower in the CFS group.Compared with the controls,the CFS patients had lower FA in WM fiber tracts of right pericallosal frontal（PCF） and left optic radiation.Conclusion： Impairment in memory/caution is evident in the CFS children,and the impaired density or reduced myelination of WM fiber tracts of the right PCF,and the left optic radiation might be involved in their memory/caution deficits.