血管内皮抑素水平与膀胱癌诊断及预后的关系

Relationship of serum and urine endostatin level with the diagnosis and prognosis of bladder cancer

目的探讨血清、尿液中血管内皮抑素水平与膀胱癌发生、发展和预后的关系。方法采用ELISA方法检测92例膀胱癌患者(膀胱癌组)与50名体检健康者(对照组)血清和尿液血管内皮抑素水平。结果膀胱癌组血清和尿液血管内皮抑素水平高于对照组(P<0.01);膀胱癌患者尿液血管内皮抑素水平在有无淋巴结转移与不同病理分级上差异有统计学意义(P<0.05),血清血管内皮抑素水平在有无淋巴结转移上差异有统计学意义(P<0.01);血清和尿液血管内皮抑素水平诊断膀胱癌的AUC分别为0.694和0.857(P<0.01);血清和尿液中血管内皮抑素水平高的膀胱癌患者生存率明显低于血管内皮抑素水平低者(P<0.05)。结论血清和尿液血管内皮抑素水平可用于膀胱癌的辅助诊断和预后评估。

Objective To assess the relationship of serum and urine endostatin levels with the development, progression and prognosis of bladder cancer. Methods Ninety-two patients with bladder cancer and fifty healthy controls were detected serum and urine endostatin levels with ELISA method. Results The levels of endostatin in serum and urine in bladder cancer group were significantly higher these those in control group （P〈0.01）. The urine endostatin level showed a significant difference between patients with and without lymph node metastasis, and in different tumor grades （P〈0.01）, and the serum endostatin level showed a significant difference only between patients with and without lymph node metastasis （P〈 0.01） in bladder cancer group. AUC of serum and urine endostatin was 0. 694 and 0. 857, respectively （P〈0.01）. The survival rate was lower in patients with high serum and urine endostatin levels than that in patients with low endostatin levels （P〈0.05）. Conclusion The detection of serum and urine endostatin levels can be used in the anxiliary is of a great help diagnosis and prognosis of bladder cancer.