药用渗透型树脂尤特奇RL合成工艺研究

Study on synthesis technology of osmotic acrylic resin eudragit RL for drug delivery

甲基丙烯酸甲酯、丙烯酸乙酯、甲基丙烯酸氯化三甲胺基乙酯为原料,偶氮二异丁酸二甲酯为引发剂,采用分段聚合的方法,制备药用渗透型丙烯酸树脂尤特奇RL。以结构表征和理化性能试验,考察聚合方法的可行性。

Osmotic acrylic resin Eudragit RLfor drug delivery was prepared by the solution of segmented polymerization using methyl methacrylate and ethyl acrylate and methacrylic acid amino ethyl trimesoyl chloride as raw material,and dimethyl 2,2＇ -azobis （2-methylpropionate） as initiator. The feasibility of the method was discussed by means of the chemical composition and physical properties.