TNFAIP3和TNIP1基因在寻常型银屑病中的表达及意义

Significance of TNFAIP3 and TNIP1 gene expression in psoriasis vulgaris

目的检测轻度和中重度寻常型银屑病患者的皮肤中肿瘤坏死因子-α诱导蛋白质3(TNFAIP3)和TNFAIP3相互作用蛋白质1(TNIP1)mRNA表达。方法采用实时荧光定量PCR来检测20例寻常银屑病患者皮损和正常皮肤中TNFAIP3和TNIP1 mRNA表达。结果与正常皮肤相比,10例轻度银屑病患者皮损中出现TNFAIP3基因表达下调和TNIP1基因表达上调(P<0.05)。10例中重度银屑病患者的正常皮肤和皮损中,TNFAIP3和TNIP1 mRNA表达差异无统计学意义(P>0.05)。结论 TNFAIP3和TNIP1 mRNA表达异常可能在寻常性银屑病的早期发挥作用。

Objective To observe the expression of tumor necrosis factor alpha-induced protein 3 （TNFAIP3） and TNFAIP3 interacting protein 1 （TNIP1） mRNA in the skin of patients with various degrees of psoriasis vulgaris （PV）. Methods The expression of TNFAIP3 and TNIP1 mRNA was detected by quantitative real-time PCR in the skin lesion and normal-appearing skin of 20 PV patients. Results Compared with the normal-appearing skin, expression of TNFAIP3 mRNA decreased, but that of TNIP1 mRNA increased in the skin lesions of 10 cases of mild PV （P〈0.05）. However, no statistical difference was observed in TNFAIP3 and TNIP1 mRNA expression between skin lesion and normal-appearing skin in 10 cases of moderate to severe PV （P〉0.05）. Conclusion The abnormal expression of TNFAIP3 and TNIP1 mRNAmay play a role in the early stage of mild PV.