摘要
目的探讨血清硫氧还蛋白(TRX-1)水平与幽门螺杆菌(H.pylori)感染及胃黏膜病理改变的关系,进一步明确其临床意义。方法选择2009年4—7月于北京大学第三医院进行胃镜检查的患者116例,于胃镜检查前抽血检测血清TRX-1水平,同时检测血清H.pylori抗体。检测方法采用酶联免疫吸附实验(ELISA)法。所有患者进行胃镜检查时于胃窦和胃体分别钳取至少一块组织进行病理组织学HE染色及Warthin-Starry染色。结果H.pylori阳性患者血清TRX-1水平(9.45 ng/ml)高于H.pylori阴性患者(8.99 ng/ml),但差异无统计学意义(U=1 488.000,P=0.775)。慢性浅表性胃炎(CSG)患者血清TRX-1水平(8.98 ng/ml)低于慢性萎缩性胃炎(CAG)患者(10.40 ng/ml),但差异无统计学意义(u=1 068.000,P=0.641)。无论在CSG还是CAG患者,H.pylori感染与否对血清TRX-1水平影响间差异均无统计学意义(P值分别为0.475和0.423)。男性患者血清TRX-1水平(8.24ng/ml)低于女性患者(10.27 ng/ml),差异有统计学意义(P=0.044)。结论 H.pylori感染与否对血清TRX-1水平无影响,在胃黏膜不同炎性状态下,以及不同炎性状态下H.pylori感染与否,血清TRX-1水平没有差异,性别对血清TRX-1水平可能有影响。
Objective To investigate the association of serum TRX - 1 level with helicobaeter pylori （ H. pylori） infec- tion and pathological changes of gastric mucosa. Methods Totally 116 patients who underwent gastroseopy between April and July 2009 in our hospital were enrolled. The serum TRX - 1 level and serum antibodies against H. pylori were examined with ELISA for all patients before gastroscopy. All patients underwent gastroscopic biopsies from gastric antrum and gastric body for HE and Warthin - Starry staining for judging H. pylori infection status. Results No significant difference of serum TRX - 1 lev- els was observed between H. pylori - positive patients and H. pylori - negative patients （9. 45 ng/ml vs 8.99 ng/ml; P = 0. 775 ） or between chronic superficial gastritis （CSG） patients and chronic atrophy gastritis （CAG） patients （8.98 ng/ml vs 10. 40 ng/ ml ; P = 0. 641 ）. H. pylori status did not significantly affect serum TRX - 1 levels in both CSG and CAG patients （ P = 0. 475, 0. 423 ）. Significant difference of serum TRX - 1 levels was observed between male and female patients （ 8.24 ng/ml vs. 10. 27 ng/ml; P = 0. 044）. Conclusion Serum TRX - l level is not associated with H. pylori infection or different pathological chan- ges of gastric mucosa. However, it may be associated with gender.
出处
《中国全科医学》
CAS
CSCD
北大核心
2012年第26期3015-3017,共3页
Chinese General Practice
