一锅法合成3,4-二氢嘧啶-2(1H)-酮

One-Pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-Ones

苦味酸催化下,芳香醛、β-酮酸酯、脲或硫脲(物质的量比1∶1∶1.15)在水中环化缩合,合成3,4-二氢嘧啶-2-酮及其衍生物.反应时间2～3 h,产率75%～98%.

3, 4- dihydropyrimidine -2（1H） -Ones and their derivatives were synthesized in high yields by onepot three component beginelli reactions of aldehydes, β- dicarbonyl compounds, urea or thiourea catalytic by picric acid. The reaction time need 2 - 3 h, The final yield was 75% - 98%.