脑梗死各种危险因素的相关性研究

Correlation Study of Cerebral Infarction Risk Factors

目的分析脑梗死患者的颈动脉内膜-中层厚度(IMT)、斑块性质与各种危险因素间的相关性。方法选取我院神经内科住院治疗的脑梗死患者257例,对患者的年龄、高血压、吸烟、饮酒、血糖、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、颈动脉IMT及颈动脉斑块进行记录,使用统计学分析方法分析。结果分析后发现,不同年龄阶段,IMT存在差异,各年龄段间两两比较,差异均有统计学意义(P<0.05);患者IMT值与LDL之间:R=23.328、标准化系数=0.810(t=13.415、P<0.05)。颈动脉粥样硬化斑块与LDL的相关系数为:Sig=0.009,Exp(B)=4.758;与Fg的相关系数为:Sig=0.028,Exp(B)=0.999。结论随着年龄的增长,IMT逐渐增厚,成为脑梗死的重要危险因素;血浆纤维蛋白原(Fg)是脑梗死的重要危险因素,具有相对独立性,对其进行干预,可以有效降低脑梗死发病率。

Objective Analysis of cerebral infarction in patients with carotid artery intima -media thickness, plaque and various risk factors correlation. Methods In our hospital 257 Eases of patients with cerebral infarction neurological depart- ment of internal medicine in hospital, patient age, hypertension, smoking, drinking, glucose, TG, TC, LDL, HDL, IMT in carotid artery and carotid plaque were recorded, using statistical analysis methods analysis. Results Analysis of the results found, different ages, IMT existence difference, age compared, the differences were statistically significant （ P 〈 0. 05 ） ; pa- tients with IMT value and LDL： R = 23. 328, standardized cofficients beta = 0. 810 （ t = 13. 415, P 〈 0. 05 ）. Carotid athero- sclerotic plaque and coefficient correlation of LDL： Sig =0. 009, Exp （B） =4. 758; and Fg correlation coefficient was： Sig = 0. 028, Exp （B） = 0. 999. Conclusion With the increase of age, IMT thickened gradually, become an important risk factor of cerebral infarction ; LDL and Fg was important risk factor of cerebral infarction, with relative independence, to intervene, can effectively reduce the incidence rate of cerebral infarction.