低剂量氟化物对新生大鼠成骨细胞增殖的影响

The influence of low dose of fluoride on the proliferation of neonatal rat osteoblasts

氟是人体内重要的微量元素之一,低剂量的氟化物作用成骨细胞与骨代谢关系密切.成骨细胞活跃和骨转换加速是氟骨症的重要特征.研究了氟化物对成骨细胞增殖以及细胞分裂周期的影响,证实了低剂量的氟化物(2 mg/L)能引起体外培养的成骨细胞的细胞增殖并增加细胞分裂增殖的代数.

Fluorine is one of the important trace elements in the human body, and closely related to bone metabolism. Osteoblast cell activity and bone turnover acceleration is an important characteristic of skeletal fluorosis. In this work, the impact of fluorinecompotmds on osteoblast cell proliferation and cell division cycle was studied with low doses of fluoride. It was confirmed that low doses of fluoride （2mg/L） can cause osteoblast cell proliferation in vitro and accelerate the proliferation of cell division algebra.