蓬灰对大鼠胰腺及糖代谢的影响

Effect of peng-hui on glucose-metabolic in normal male SD rats

目的观察不同剂量蓬灰对正常SD雄性大鼠胰腺及糖代谢的影响。方法雄性SD大鼠60只,分别灌胃给予573、1 146、2 291 mg/kg蓬灰,对照组给予等量生理盐水,共饲养12周。饲养期间,监测空腹血糖(FBG)、空腹胰岛素(FINS)变化;于饲养12周龄时,取胰腺组织进行HE染色,观察胰腺组织的病理学改变。结果与对照组比较,实验组的FBG、FINS水平差异均无统计学意义(P>0.05)。实验组胰腺HE染色显示血管扩张充血。结论蓬灰对正常雄性SD大鼠糖代谢可能无影响,但对胰腺会造成一定的损伤。

Objective To investigate the effects of peng - hui of different dose on glucose - metabolic in normal male SD rats. Methods 60 Male SD rats were respectively irrigated peng - hui of 573 mg/kg, 1146 mg/kg, 2291 mg/kg, and the rats were adminis- trated equal amount saline in control group. The feeding time was maintained for 12 weeks. And fasting blood glucose （FBG） and fast- ing plasma insulin （FINS） were monitored during feedings, pancreas was taking for coloration of HE, then pathematology change was in- spected. Results Compared with the control group, there were no differences in FBG and FINS among the experimental groups （ P 〉0. 05）. Compared with the control group, HE staining showed pancreatic vascular dilatation and congestion in the experimental group. Conclusion There is no effect on peng -hui in the sugar metabolism in normal rats, but the pancreas may damage.