ICU痰培养鲍曼不动杆菌耐药性变迁分析

Change of drugs resistance of Acinetobacter baumannii cultivated from sputum in ICU

目的探讨ICU患者痰培养中鲍曼不动杆菌对常用抗菌药物耐药性变迁,为临床和医院感染管理提供第一手资料。方法通过回顾性调查分析2008～2011年ICU痰培养中鲍曼不动杆菌耐药性的变迁。结果 2008～2011年ICU痰培养分离鲍曼不动杆菌185株,每年的构成比均占首位(分别为25.0%、18.2%、26.7%、26.8%)。鲍曼不动杆菌对常用药物的耐药率均超过50%;全耐药菌株检出率2010～2011年与2008～2009年比较呈明显上升趋势(P<0.05)。结论 ICU鲍曼不动杆菌耐药情况严重,应采取必要措施,减少细菌耐药的发生。

Objective To get knowledge of the drugs resistance change of Acinetobacter baumannii in ICU, so as to offer the first-hand information to the clinical preventive and therapeutic countermeasures. Methods Retrospective investigation was used to analyze Acinetobacter baumannii resistant bacteria changes of sputum culture results in our ICU from 2008 to 2011. Results Totally Acinetobacter baumannii 185 strains were mainly isolated from samples of sputum from 2008 to 2011, The constituent ratio of each year accounted for firs＇t place（25.0%, 18.2 %, 26.7 %, 26.8 %, respectively）. Drugs resistant rate of Acinetobacter baumanii to commonly used drugs were over 50.0 %. Pandrug-resistant Acinetobacter baumannii strains were increased in 2010- 2011 compared with 2008--2009（P〈0.05）. Conclusion It was showed that Acinetobacter baumannii was high drugs resistance. Doctors should pay more attention to analyze the bacterial resistance profile in order to decrease the incidence of drug resistance.