胱抑素C与冠心病严重程度及对经皮冠状动脉介入治疗患者预后的关系

The relationship between cystatin C and coronary heart disease severity and prognosis after PCI

目的验证血浆Cys-C与冠心病严重程度及对经皮冠状动脉介入治疗(PCI)患者预后的关系。方法选择2010年1月至2011年12月本院住院接受PCI的患者300例,按病情分为3组,SAP患者100例为SAP组,UAP患者100例为UAP组,AMI患者100例为AMI组。并选择同期冠状动脉造影正常的100例健康者为对照组。比较各组血胱抑素C(Cys-C)、高敏C反应蛋白(hs-CRP)指标及主要心血管事件的发生情况。结果 AMI组患者的Cys-C水平高于对照组、UAP组和SAP组(P<0.05)。结论 Cys-C水平与冠脉病变严重程度有关,同时是MACE发生的强预测因子。

Objective To investigate the changes of plasma cystatin C concentration（Cys-C） ,and to evaluate the relationship be tween Cys-C and acute coronary syndrome. Methods A total of 300 consecutive patients accepted PCI in our hospital from ,Jan. 2010 to Nov. 2011 were enrolled in this study,consisting of 100 patients with stable angina pectoris（SAP）, 100 patients with unsta ble angina pectoris（UAP）, 100 patients with acute myocardial infarction（AMl）, and 100 healthy subjects as controls. Plasma cysta tin C,high sensitivity C-reactive protein（hs-CRP）in all subjects were examined. Results Cystatin C levels were significantly higher in AMI patients than those in controls,UAP and SAP patients（P〈0.05）. Conclusion Cystatin C plays an important role in the development of CAD and Cys-C is a strong predictor for risk of MACE.