益气通瘀法对多器官功能障碍肠道屏障保护作用临床研究

Clinical Research of Yiqitongyu Method in Protection Intestinal Barrier in Patients with Multiple Organ Dysfunction Syndrome

目的观察益气通瘀法对多器官功能障碍患者肠道屏障功能的保护作用及对全身炎症反应的影响。方法将多器官功能障碍患者40例随机分为两组,对照组给予常规治疗,实验组在常规治疗的基础上经鼻胃管或鼻肠管给予益气通瘀汤药;观察两组患者用药前、用药后第3、7、14日的胃肠功能评分、二胺氧化酶、D-乳酸、内毒素、C反应蛋白、APACHEⅡ评分以及Marshall评分。结果用药后第3日,两组二胺氧化酶水平变化差异有统计学意义;用药后第7日,两组胃肠功能评分及D-乳酸差异有统计学意义;用药后第14日,两组C反应蛋白及内毒素水平差异有统计学意义,APACHEⅡ评分及Marshall评分差异无统计学意义。结论益气通瘀法可改善肠黏膜屏障功能,减轻全身炎症反应。

Objective： To observe the validity of Yiqitongyu method in protection intestinal barrier of patients with multiple organ dysfunction syndrome （MODS） and its influence to systemic inflammatory response. Methods： 40 patients with MODS were divided into 2 groups. On the basis of the routine therapies in 2 groups. The experi- mental group was added the Yiqitongyu Herbs. Some indices were compared in 2 groups including the gastroin- testinal function score, the diamine oxidase （DAO）, the D-lactic acid, the endotoxin, the C reactive protein （CRP）, the APACHE Ill score and the Marshall score before therapy,3 days,7 days and 14 days after therapy. Results： 3 days after therapy,there was a significantly difference in the DAO in 2 groups. 7 days after therapy,there were some obvious differences in the gastrointestinal function score and the D- lactic acid between 2 groups. 14 days after therapy,the endotoxin and the CRP were significantly different in the experiment group comparing the control group. However,the APACHE Ⅱ score and the Marshall score in the experiment group were no remarkable dif- ferences when they compared with the control group. Conclusion： Yiqitongyu method could improve gastrointesti- nal function and reduce systemic inflammatory response.