颗粒细胞与卵母细胞发育

Granulosa and Oocyte Development

颗粒细胞在卵母细胞发育、成熟中起着重要的营养及信号传导作用,同时卵母细胞对颗粒细胞的分化及发育也起着中心调节作用。研究颗粒细胞的基因表达改变可以对卵母细胞发育的微环境进行评估。颗粒细胞基因差异表达可能与卵母细胞质量有关,有可能通过对颗粒细胞基因表达谱的分析,寻找卵母细胞及胚胎选择的生物标记,以提高体外受精的受精率、胚胎种植率及临床妊娠率,降低流产率。

Granulosa is important in the nutrition and signal transduction for oocyte development and maturation. Similarly ,oocyte also plays regulating roles in the granulosa differentiation and development. The profile of gene expression of granulosa may be used to evaluate the micro-environment of oocyte development. The patterns of gene expression of granulosa may be associated with the oocyte quality. Therefore, it is possible to identify the markers of oocyte and embryo competence by analyzing the granulosa transcriptome, by which the IVF fertilization rate, implantation rate and pregnancy rate could be increased, and the miscarriage rate decreased.