女性血液系统恶性肿瘤的生殖保护策略

The Fertility Preservation for Female with Hematologic Malignant Tumor

血液系统恶性肿瘤是造血系统的恶性疾病,发病率在患恶性肿瘤的年轻人中居首位。化疗是其早期治疗的主要手段,但这会对女性的卵巢结构和功能产生严重的甚至是不可逆的损害。因此,对于患有血液系统恶性肿瘤的妇女,既要保护其卵巢的生殖功能,又不能影响其原发病的治疗效果。目前可能有效的生殖保护手段是胚胎冷冻、卵子冷冻、卵巢及卵巢组织冷冻、卵巢移位、促性腺激素释放激素(GnRH)类似物、避孕药和激素疗法等。

Blood system malignant tumor is a group of malignant diseases with the highest incidence in youth.For the early treatment,chemotherapy is of first choice.Chemotherapy will produce serious and irreversible damage for ovarian structure and function.So far the female with blood system malignant tumor,the primary chemotherapy should be carried with consideration of the fertility preservation of ovary.At present,the possible methods of effective fertility preservation are embryo cryopreservation,mature and immature oocyte cryopreservation,ovarian and ovarian tissue cryopreservation,ovarian transplantation,GnRH-analogues usage,oral contraceptive,hormone replacement therapy and so on.