多沙唑嗪控释片治疗输尿管下段结石疗效分析

Clinical research of doxazosin mesylate controlled release tablets in the treatment of lower ureteral stones

目的评估多沙唑嗪控释片治疗输尿管下段结石的排石疗效。方法收集输尿管下段结石病例共121例,所有结石均经B超、CT或静脉肾盂造影检查确诊,结石大小4～10mm,病例随机分成两组:治疗组59例,采用多沙唑嗪控释片+肾石通治疗;对照组62例,单独采用肾石通治疗,比较两组在结石排出时间、结石排出率、肾绞痛发作次数上是否存在差异。结果对照组结石完全排出28例,排石率为45.16%;治疗组结石完全排出45例,排石率为76.27%,两组比较,差异有统计学意义(χ2=12.23,P<0.05)。对照组平均排出结石时间为(15.78±3.08)d,治疗组为(12.59±2.83)d,两组比较,差异有统计学意义(t=4.68,P<0.05);对照组肾绞痛发生率为17.74%,治疗组肾绞痛发生率为6.78%,两组比较,差异具有统计学意义(χ2=3.34,P<0.O5)。结论多沙唑嗪控释片能明显促进下段输尿管结石的排出,减少肾绞痛的发生。

Objective To evaluate the clinical effect of doxazosin mesylate controlled release tablets in the treatment of lower ureteral stones. Methods A total of 121 patients with lower ureteral stones diagnosed by ultrasound, CT or KUB＋ IVP were randomized into two groups： experimental group （59 patients） was given Doxazosin and Shenshitong. Control group （62 patients） was given only Shenshitong. Calculus expulsion time, calculus expulsion rate and renal colic episodes in the two groups were compared. Results The calculus expulsion rate of experimental group （76.27%） was significantly higher than that of the control group （45.16%） （x2=12.23,P〈0.05）. The calculus expulsion time of experimental group （12.59±2.83） was shorter than that of the control group （15.78±3.08） （t=4.68,P〈0.05）. The renal colic episodes rate of control group （17.74%） was higher than that of the experimental group （6.78%）（X2=3.34, P〈0.05）. Conclusions The doxazosin mesylate controlled release tablets can significantly increase the expulsion rate in lower ureteral stones and reduce the occurring of renal colic episodes.