Bcl-2、MMP-9和Ki67在翼状胬肉中的表达及其意义

Expression and function of Bcl-2 、MMP-9 and Ki67 in pterygium

目的研究翼状胬肉组织中Bcl-2、基质金属蛋白酶-9(MMP-9)和Ki67的表达,以探讨Bcl-2、MMP-9和Ki67的表达与翼状胬肉之间的关系,以及翼状胬肉与肿瘤之间的关系。方法应用免疫组织学法检测76例翼状胬肉组织中Bcl-2、MMP-9和Ki67的表达,并与9例正常结膜组织进行比较。结果翼状胬肉组织中Bcl-2、MMP-9和Ki67的表达均高于正常结膜组织。翼状胬肉组织中Bcl-2和MMP-9阳性表达间存在正相关(r>0,P<0.05)。结论 Bcl-2、MMP-9和Ki67的高表达在翼状胬肉的发生和发展中起着重要作用,翼状胬肉与肿瘤有一定相关性。

Objective To study the expression and the relationship of B-cell lymphoma/leukemia-2 （ Bcl-2 ）, matrix metalloproteinnses-9 （MMP-9） and Ki67 in pterygium, and the relationship of pterygium and tumor. Methods The expression of Bcl-2 , MMP-9 and Ki67 were detected in 76 cases with pterygium by immunohi method and were compared with the normal conjunctiva epithelium in other 9 cases. Result The expression of Bcl-2 , MMP-9 and Ki67 were higher in pterygium than in normal conjunctiva epithelium（ P 〈0.05 ）. The expression of Bcl-2 was related to that of MMP- 9. Conclusion The increase of Bcl-2 and MMP-9 are presented in pterygium, which may play an important role in the origin and development of pteryglmn . Pterysium has some relationgship with tumor.