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NT-proBNP在急诊危重病中的诊断价值 被引量：3

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摘要 脑钠肽（B-type-NatriureticPeptide，BNP）由日本学者Sudoh等于1988年首先在猪脑中发现^[1]，而Hunt等^[2]在1995年第一次对N-端脑钠肽前体（N-terminal-pro-BNP，NT-proBNP）进行了描述。BNP主要由左心室分泌，在心肌细胞受到容量负荷和压力负荷增高时，非活性前体Pro-BNP裂解为活性BNP和非活性的NT-proBNP^[3]。
作者 商娜 张源波 周荣斌 张晓云
机构地区 北京军区总医院急诊科
出处 《中国循证心血管医学杂志》 2012年第4期376-377,共2页 Chinese Journal of Evidence-Based Cardiovascular Medicine
关键词 PROBNP 诊断价值 危重病 脑钠肽前体 急诊 NT HUNT 压力负荷
分类号 R446 [医药卫生—诊断学]
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参考文献24

  • 1Soudoh T,Minamio N,Kangawa K,et al.C-type natriuretic peptide(CNP):a new member of natriuretic peptide familyidentifiend in porcine brain[J].Biochem Biophys Res Commun,1990,168(2):863-70.
  • 2Hunt PJ,Yandle TG,Nicholls MG,et al.The amino-terminal portion of pro-brain natriuretic peptide(Pro-BNP) circulates in human plasma[J].Biochem Biophys Res Commun,1995,214(3):1175-83.
  • 3de Denus S,Pharand C,Williamson D,et al.Brain natriuretic peptide in the management of heart failure:the versatile neurohormone[J].Chest,2004,125(2):652-68.
  • 4Lainchbury JG,Troughton RW,Strangman KM,et al.N-terminal pro-B-type natriuretic peptide-guided treatment for chronic heart failure:results from the BATTLESCARRED (NT-proBNP-assisted treatment to lessen serial cardiac readmissions and death) trial[J].J Am Coll Cardiol,2009,55(1):53-60.
  • 5Krackhardt F,Dungen HD,Trippel TD,et al.N-terminal pro-Btype natriuretic peptide and long-term mortality in non-ischaemic cardiomyopathy[J].Wien Klin Wochenschr,2011,123(23-24):738-42.
  • 6Silvers SM,Howell JM,Kosowsky JM,et al.Clinical policy:critical issues in the evaluation and management of adult patients presenting to the emergency department with acute heart failure syndromes[J].Ann Emerg Med,2007,49(5):627-69.
  • 7Carpenter CR,Keim SM,Worster A,et al.Brain natriuretic peptide in the evaluation of emergency department dyspnea:is there a role[J]? J Emerg Med.,2012,42(2):197-205,.
  • 8Luchner A,Mockel M,Spanuth E,et al.N-terminal pro brain natriuretic peptide in the management of patients in the medical emergency department (PROMPT):correlation with disease severity,utilization of hospital resources,and prognosis in a large,prospective,randomized multicentre trial[J].Eur J Heart Fail,2012,14(3):259-67.
  • 9Ma KK,Ogawa T,de Bold AJ.Selective upregulation of cardiac brain natriuretic peptide at the transcriptional and translational levels by pro-inflammatory cytokines and by conditioned medium derived from mixed lymphocyte reactions via p38 MAP kinase[J].J Mol Cell Cardiol,2004,36(4):505-13.
  • 10Tanaka T,Kanda T,Takahashi T,et al.Interleukin-6-induced reciprocal expression of SERCA and natriuretic peptides mRNA in cultured rat ventricular myocytes[J].J Int Med Res 32(1):57-61.

同被引文献38

  • 1Ghaye B,Ghuysen A,Willems V,et al.Severe pulmonary embolism:pulmonary artery clot load scores and cardiovascular parameters as predictors of mortality[J].Radiology,2006,239:884-891.
  • 2Qanadli SD,E1 Hajjam M,Vieillard-Baron A,et al.New CT index to quantify arterial obstruction in pulmonary embolism:comparison with angiographic index and echocardiography[J].AJR Am J Roentgenol,2001,176:1415-1420.
  • 3Mastora I,Remy-Jardin M,Masson P,et al.Severity of acute pulmonary embolism:evaluation of a new spiral CT angiographic score in correlation with echocardiographic data[J].Eur Radiol,2003,13:29-35.
  • 4Ryu JH,Pellikka PA,Froehling DA,et al.Saddle pulmonary embolism diagnosed by CT angiography:Frequency,clinical features and outcome[J].Respir Med,2007,101:1537-1542.
  • 5Yusuf SW,Gladish G,Lenihan D J,et al.Computerized tomographic finding of saddle pulmonary embolism is associated with high mortality in cancer patients[J].Intern Med J,2010,40:293-299.
  • 6Liu M,Ma Z,Guo X,et al.Computed tomographic pulmonary angiography in the assessment of severity of chronic thromboembolic pulmonary hypertension and right ventricular dysfunction[J].Eur J Radiol,2011,80:e462-e469.
  • 7Miller GA,Sutton GC,Kerr IH,et al.Comparison of streptokinase and heparin in treatment of isolated acute massive pulmonary embolism[J].Br Med J,1971,2:681-684.
  • 8Bankier AA,Janata K,Fleischmann D,et al.Severity assessment of acute pulmonary embolism with spiral CT:evaluation of two modified angiographic scores and comparison with clinical data[J].J Thorac Imaging 1997,12:150-158.
  • 9Collomb D,Paramelle PJ,Calaque O,et al.Severity assessment of acute pulmonary embolism:evaluation using helical CT[J].Eur Radiol,2003,13:1508-1514.
  • 10Engelke C,Rummeny EJ,Marten K.Acute pulmonary embolism on MDCT of the chest:prediction of cor pulmonale and short-term patient survival from morphologic embolus burden[J].AJR Am J Roentgenol,2006,186:1265-1271.

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中国循证心血管医学杂志
2012年 第4期

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