Vimentin介导LMP1在鼻咽上皮与鼻咽癌中的表达意义

Expression Significance of Vimentin Mediated LMP1 in Nasopharyngeal Epithelium and Nasopharyngeal Carcinoma

目的:观察Vimentin与LMP1蛋白在鼻咽上皮和鼻咽癌中的表达,揭示蛋白质之间的相互作用规律。方法:采用S-P免疫组织化学染色检测LMP1与Vimentin在30例鼻咽上皮组织和60例鼻咽低分化鳞状细胞癌中的表达。结果:(1)LMP1在鼻咽上皮组织与鼻咽低分化鳞状细胞癌中的阳性表达率分别为73.3%和90%;(2)与LMP1(-)组织比较,Vimentin蛋白在LMP1(+)的鼻咽上皮组织与鼻咽低分化鳞状细胞癌中升高(P<0.05)。结论:LMP1在鼻咽上皮组织与鼻咽低分化鳞状细胞癌中上调Vimentin蛋白的表达。

Objective： To observe the expression of vimentin mediated LMP1 in nasopharyngeal epithelium and nasopharyngeal carcinoma and reveal interaction regular among proteins. Method： The expression of LMP1 and vimentin proteins was detected by immunohistochemistry in 30 nasopharyngeal epithelial tissues and 60 nasopharyngeal poorly differentiated squamous-cel] carcinoma tissues. Result： （1）The positive expression rate of LMP1 protein was respectively 73.3% and 90% in nasopharyngeal epithelial tissue and nasopharyngeal poorly differentiated squamous-cell carcinoma it. （2）Compared with LMP1 negative tissue, the vimentin protein was over-expression in the nasopharyngeal epithelium of LMP1 positive tissue, and nasopharyngeal poorly differentiated squamous-cel] carcinoma（P〈0.05）. Conclusion： LMP1 regulates the expression of vimentin protein in nasopharyngeal epithelium tissue and nasopharyngeal poorly differentiated squamous-cell carcinoma it.