颈椎旁神经阻滞对颈椎间盘源性疼痛患者外周血细胞因子和T细胞亚群的影响

Cervical nerve block affect cytokines and T cell subsets in peripheral blood of patients with Cervical Discogenic Pain

目的检测颈椎旁神经阻滞治疗前后颈椎间盘源性疼痛患者外周血炎性细胞因子表达水平及T细胞亚群数量。方法选取颈椎间盘源性疼痛住院患者63例,行颈椎旁神经阻滞治疗,在治疗前、治疗后24h、3d、7d检测外周血炎性细胞因子TNF-α、IL-1、IL-6表达水平及T细胞亚群数量并进行比较。结果相对于治疗前,颈椎旁神经阻滞后24h、3d外周血炎性细胞因子TNF-α、IL-1、IL-6水平下降;外周血CD3+、CD4+、CD8+细胞数升高。结论颈椎旁神经阻滞治疗可以降低颈椎间盘源性疼痛患者外周血炎性细胞因子的表达,能够影响T细胞亚群的数量从而改善细胞免疫。

Objective To detect the inflammatory cytokine expression levels and the number of T cell subsets in peripheral blood of patients with cervical discogenic pain before and after cervical nerve block.Methods 63 cases of cervical discogenic pain hospitalized patients were selected and received Cervical nerve block therapy.Peripheral blood inflammatory cytokines TNF-α,IL-1,IL 6 level and the number of T cell subsets were detected and compare at Before treatment,24 hours,3 days,7 days after treatment.Results Compared with before treatment,peripheral blood inflammatory cytokines TNF-α,IL-1,IL-6 levels decreased and peripheral blood CD3＋,CD4＋,CD8＋ cells increased at 24 hours,three days after cervical nerve block therapy.Conclusion Paravertibral cervical nerve block treatment can reduce peripheral blood inflammatory cytokines expression and can increase the number of T cell subsets in cervical discogenic pain patientsand then improving cellular immunity.