多发性硬化合并不宁腿综合征12例临床分析

Clinical characteristics of multiple sclerosis with restless legs syndrome

目的探讨多发性硬化（MS）患者合并不宁腿综合征（RLS）的临床特点，且进一步研究MS患者合并RLS的相关因素。方法选取确诊的70例MS患者，根据是否合并RLS分为伴RLS组和单纯MS组，比较两组患者的MS发病年龄、病程及神经功能损害严重程度（EDSS评分）等临床资料；分析RLS症状严重程度与EDSS的关系。结果70例MS患者中12例合并RLS，发生率为17．1％（12／70）。伴RLS组患者发病年龄为（47．6±10．0）岁，单纯MS组为（40．1±10．4）岁，两组比较差异有统计学意义（t=2．29，P=0．030）；病程分别为（12．6±6．8）、（8．2±6．6）年，两组比较差异有统计学意义（t=2．10，P=0．039）；EDSS评分分别为（4．5±2．5）、（2．5±2．0）分，两组比较差异有统计学意义（t=3．02，P=0．004）。RLS严重程度评分与EDSS评分无相关性（r=0．45，P=0．15）。结论RLS在MS患者中发病率较高，MS发病年龄越大，病程越长，神经功能损害越严重，发生RLS的可能性越大。

Objective To investigate the clinical features of patients with multiple sclerosis （MS） and restless legs syndrome （RLS） and to further examine relevant factors that may contribute to the co-occurrence of MS and RLS. Methods Seventy MS patients were recruited in the present study. The RLS screen was further performed in MS patients based on the diagnostic criteria for RLS. MS patients with RLS were designated as the case group and MS patients without RLS served as the control group. The clinical data including age of MS onset, MS duration and clinical disability by the expanded disability status scale （EDSS） were analyzed. Results There were 12 MS patients with RLS in total 70 MS patients and the incidence rate was 17.1%. The average age of MS onset in the RLS group was （47. 6 ± 10. 0） years,and （40. 1 ± 10.4） years in the control group. The difference of average age of MS onset was found to be significant （t = 2. 29,P = 0. 030）. The average history of MS in the RLS group was （ 12.6 ± 6. 8 ） years, and （ 8. 2 ± 6. 6 ） years in the control group （ t = 2. 10, P = 0. 039）. The average EDSS of the RLS group was 4. 5 ±2. 5 ,and 2. 5 ±2. 0 in the control group （t =-3.02 ,P = 0. 004）. There was no significant association between RLSRS and EDSS in MS patients with RLS （P =0. 15）. Conclusion The incidence rate of RLS in MS patients was high. Among patients with MS, RLS was associated with older age, longer MS duration, and more severe disability.