摘要
小RNA(microRNA,miRNA)是一类长约18～25个核苷酸序列的内源性非编码单链小RNA,通过与靶基因序列特异性相互作用,在转录后水平调节基因表达,从而调控细胞增殖、分化与凋亡等过程。结直肠癌(colorectal cancer,CRC)是最常见的恶性肿瘤之一,我国CRC发病率呈逐年上升趋势,且发病年龄亦有年轻化趋势。越来越多的研究表明,特异性miRNA表达异常与CRC的发生、发展密切相关。近几年来,miRNA在CRC的诊断、靶向治疗及预后评估等方面的研究已成为热点。
microRNAs （miRNAs） are small non-coding RNAs that function as endogenous silencers of numerous target genes. Hundreds of human miRNAs have been identifed in the human genome, and they are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis and differentiation. Colorectal cancer （CRC） is one of the most common maligancies. The incidence of CRC in China is increasing annually with its incidence age gradually getting yonger. Aberrant expression of miRNAs may contribute to the development and progression of human CRC. In additon, miRNAs may provide new biomarkers for diagnosis,treatment and prognosis of CRC.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2012年第5期531-536,共6页
Fudan University Journal of Medical Sciences
基金
上海市金山区科学技术创新基金项目(2009-3-13)~~
