46例胃肠道间质瘤手术疗效分析

Efficacy of surgical treatment in 46 cases of gastrointestinal stromal tumor

目的:总结胃肠道间质瘤(GIST)的手术治疗经验。方法:回顾性分析2004年6月至2011年6月广东省梅州市人民医院收治的46例GIST患者的临床资料。分别采取胃部分切除、胰十二指肠切除、联合脏器切除等术式。结果:除1例盆腔巨大间质瘤未能完整切除外,其余患者的肿瘤均完整切除。1例直肠间质瘤并输尿管侵犯的女性患者,术后1年左右复发死亡,其他患者术后中位生存期均超过2年。结论:GIST手术应坚持肿瘤完整切除,手术切缘的距离和手术方式的选择,应根据肿瘤危险度的大小、肿瘤的部位及生长方式灵活掌握。

Objective： To evaluate the efficacy of surgical treatment for gastrointestinal stromal tumor （GIST）. Methods： A retrospective study was conducted in 46 GIST patients registered to Meizhou Municipal People＇ s Hospital between June 2004 and June 2011. The surgical options in these patients included subtotal gastrectomy, segmental resection of small intestine, and Whipple＇ s operation., Results ： Curative resection were successful in all patients except for 1 case of giant pelvic stromal tumor. One women with rectal lesions and involvement of ureters died of tumor recurrence after surgery, and the remaining patients survived the second year post-operation. Conclusion： Complete resection of local tumors remains the principle for surgical treatment of GISTs. Determination of surgical margins and options should flexibly depend on the risk, location and growth of local lesions.