肺癌患者术后生活质量变化特点及影响因素

Characteristics of postoperative life quality change in patients with lung cancer and it's influencing factors

目的:探讨肺癌患者术后4个月内症状和生活质量的变化特点并分析相关影响因素。方法:用中文版欧洲癌症研究和治疗协作组生活质量核心问卷(European organization for research and treatment of cancer quality of life questionnaire-core 30,EORTC QLQ-C30)和肺癌特异性问卷(EORTC QLQ-lung cancer 13,EORTC QLQ-LC13)对113例肺癌患者术后第1、2、4个月的生活质量进行调查,数据采用描述性统计和多元线性回归等方法进行分析。结果:术后第4个月时除了认知功能,其他功能和整体生活质量均显著提高(P<0.05);疲乏、气促、疼痛、食欲丧失、咳嗽、胸痛、手或肩部疼痛均显著缓解(P<0.05),手足刺痛显著恶化(P<0.05),其他症状无显著性变化。生活质量的影响因素包括抑郁、吸烟史和辅助治疗。结论:术后第4个月时,患者的整体生活质量显著提高,大多数症状得到缓解,但疲乏和角色功能障碍持续存在,应得到医护及患者的共同关注。

Objectives：To research into the characteristics of changes of life quality and symptom at 4 months postoperatively in patients with lung cancer and to analyze its influencing factors. Methods：The life quality of 113 patients with lung cancer at the 1st, 2nd and 4th months after surgery was assessed by using the Chinese version of European organization for research and treatment of cancer quality of life questionnaire-core 30（EORTC QLQ-C30） and EORTC QLQ-lung cancer 13 （EORTC QLQ-LC13） scale and the data were analyzed by adopting descriptive statistics and multiple linear regression. Results：At the 4 th months, the function and overall life quality of patients were improved significantly except cognitive function（P〈0.05）. Fatigue, dyspnoea, appetite loss, coughing,chest pain,pain in the arm or shoulder were alleviated significantly（P〈0.05）,however,stabling pain in the hands and feet was worsened（P〈0.05） ,other symptoms has no significant changes. The influencing factors of life quality included depression,smoking history and adjuvant therapy. Conclusions：At the 4th month after the surgery, the overall life quality is improved and most symptoms are eased, however,fatigue and role function obstacle are still existed and should be attached importance to.