新生儿泪囊炎发病危险因素的病例对照研究

Case-control Study on Risk Factors of Neonatal Dacryocystitis

【目的】探讨与新生儿泪囊炎发生有关的危险因素。【方法】采用病例对照研究方法 ,收集2011年门诊诊治的新生儿泪囊炎患儿150例及正常对照150例,对照组为非调查因素相同的非新生儿泪囊炎儿童。采用单因素及多因素非条件Logistic回归分析进行新生儿泪囊炎的危险因素分析。【结果】经过单因素及多因素非条件Logistic回归分析最终筛选出与新生儿泪囊炎发生相关的3个危险因素,分别为孕周小于37周(OR值为4.922),出生体质量大于4 kg(OR值为2.418)和有鼻炎家族史(OR值为2.453)。【结论】早产、巨大儿以及鼻炎家族史是新生儿泪囊炎的高危因素。

[ Objective ] To investigate the risk factors associated with the occurrence of neonatal dacryocystitis. [ Methods ] A case-control study was conducted. 150 infants with neonatal dacryocystitis and 150 normal control were screened from patients of Guangzhou Women and Children＇s Medical Center. The Controls were non-neonatal daeryoeystitis infants and their non-investigation factors are the same. The risk factors of neonatal dacryocystitis were analyzed by univariate and multivariate unconditional Logistic regression analysis. [ Results ] Three risk factors were screened to be associated with the occurrence of neonatal dacryocystitis, including Gestational age less than 37 weeks （OR, 4,922）, birth mass of more than 4 kg （OR, 2.418） and family history of rhinitis （OR, 2.453）. [ Conclusion： ] Preterm birth, macrosomia and family history of rhinitis are major risk factors contributing to neonatal dacryocystitis in neonates.