甘精胰岛素联合阿卡波糖在门诊治疗初诊2型糖尿病的临床观察

Clinical observation on insulin glargine combined with acarbose in outpatient treatment of newly diagnosed type 2 diabetes

目的探讨甘精胰岛素联合阿卡波糖在门诊治疗初诊2型糖尿病的治疗价值。方法将56例门诊初诊2型糖尿病患者[糖化血红蛋白(HbA1c)>9%]随机分为治疗组及对照组,每组28例。治疗组使用甘精胰岛素联合阿卡波糖,对照组使用门冬胰岛素30注射液(诺和锐30R)联合阿卡波糖,治疗4周。两组患者年龄、体质量指数(BMI)、空腹C肽(FCP)、空腹血糖(FPG)、餐后2小时C肽(2hCP)、餐后2小时血糖(2hPG)、HbA1c等比较,差异无统计学意义(P>0.05)。结果两组患者经治疗后均有效,FPG、血糖谱(即三餐前血糖、三餐后2小时血糖、睡前血糖7个时间点)测得平均血糖(PG)较治疗前均明显下降(P<0.01)。FCP、2hCP较治疗前升高(P<0.05)。两组患者达到理想的相同的血糖水平所需时间及低血糖发生率比较,差异无统计学意义(P>0.05)。结论对空腹血糖升高为主的初诊2型糖尿病患者在门诊治疗选择甘精胰岛素与阿卡波糖联合是一种方便、安全、有效的方法,患者依从性高。

Objective To investigate the curative value of insulin glargine combined with acarbose in the outpatient treatment of newly diagnosed type 2 diabetes mellitus（T2DM）.Methods 56 outpatients with newly diagnosed T2DM（HbA1c〉9%） were randomly divided into the treatment group and the control group,28 cases in each group.The treatment group used insulin glargine combined with acarbose and the control group was given BIAsp30 plus accarbose for 4-week treatment.Age,BMI,and FCP,FPG and 2 hCP,2 hPG,HbA1c had no statistical differences between the two groups（P〉0.05）.Results The two groups alll had effects after treatment,FPG and 2 hPG were significantly decreased than before treatment（P0.05）.Conclusion In the patients with newly diagnosed T2DM and dominated by increased FPG,selecting insulin glargine and acarbose combination is a convenient,safe,effective treatment method with high patient compliance in outpatient treatment.