摘要
目的探讨MCF2细胞源性转化序列样2(MCF2L2)基因多态性与我国多囊卵巢综合征(PCOS)发病易感性的关系。方法以PCOS先证者及其父亲、母亲所组成的满足经典TDT分析的核心家庭为研究对象,在152个山东汉族核心家系中采用TaqMan探针与直接测序法检测MCF2L2基因多态性。结果 rs35368790位点G等位基因多态性传递不平衡(χ2=7.118,P<0.05),G等位基因在患病子代中的传递过多。结论 MCF2L2基因rs35368790位点多态性与PCOS的发病易感性相关,G等位基可能是增加其发病风险的关键等位基因。
Objective To explore the correlation between MCF2 cell line-derived transforming sequence like 2 （MCF2L2） gene polymorphisms and the susceptibility of polycystic ovary syndrome （PCOS） in China. Methods The object of this study was PCOS probands and their parents meeting the classic TDT analysis of the core family. Genotyping was done by Taq- Man probe and direct sequencing in 152 Han people families of Shandong province. Results The G allele polymorphism in rs35368790 was transmission disequilibrium （x^2 =7. 118,P〈0.05）, excessive transmission of the G allele in the prevalence of sick offspring. Conclusion MCF2L2 gene rs35368790 polymorphism is associated with susceptibility to PCOS. The G allele is likely to be the key allele responsible for the risk of PCOS.
出处
《齐鲁医学杂志》
2012年第6期497-499,501,共4页
Medical Journal of Qilu
基金
中加合作自然科学基金项目(30611120524)
