文拉法辛并喹硫平治疗难治性抑郁症效果比较

THE EFFECT OF VENLAFAXINE COMBINING WITH QUETIAPINE IN THE TREATMENT OF REFRACTORY DEPRESSION

目的观察文拉法辛并喹硫平治疗难治性抑郁症的效果。方法将61例难治性抑郁症病人随机分为文拉法辛合并喹硫平组(研究组)和文拉法辛组(对照组),疗程8周。分别于治疗前及治疗后1、2、4、8周末以汉密尔顿抑郁量表(HAMD)评估疗效与安全性。结果治疗结束后,两组HAMD评分较治疗前显著降低(t=21.85、17.86,P<0.05),治疗第2、4、8周末,研究组HAMD评分显著低于对照组,差异有显著性(t=2.25～3.05,P<0.05)。两组未见明显副作用。结论文拉法辛并喹硫平治疗难治性抑郁症效果更佳,安全性更高。

Objective To investigate the clinical efficacy of venlafaxine combined with quetiapine in the treatment of re- fractory depression. Methods A total of 61 patients were randomized to study group, treated with venlafaxine combined with quetiapine, and control group, treated with venlafaxine. The course was for eight weeks. The efficacy and side effects were evalua- ted using Hamilton Depression Rating Scale （HAMD） after 1, 2, 4, and 8 weeks after therapy. Results Scores of HAMD in the two groups decreased significantly after completion of the treatment （t = 21.85,17.86;P〈0. 05）. The score of HAMD in Study group was significantly lower than that in control group at the end of weeks 2, 4 and 8 （t=2.25-3.05,P〈0.05）. No significant side effects were noted in the two groups. Conclusion The efficacy of cotherapy with venlafaxine and quetiapine for refractory depression is much better than with venlafaxine alone.