铜绿假单胞菌医院感染现状及其耐药性探讨

Investigation of pseudomonas aeruginosa infection and drug resit

目的:分析219株铜绿假单胞菌医院感染的现状及其耐药性,为临床医师合理用药提供科学依据。方法:按照《全国临床检验操作规程》,对219株铜绿假单胞菌进行培养和鉴定,药敏实验采用纸片扩散法(K-B法)。结果:219株PAE主要分布在重症监护病房(ICU)、呼吸科、内科、外科病区,分别占31.1%、24.7%、18.7%;主要于痰、脓液及分泌物、尿液、胸腹水、血液中检出,分别占55.3%、18.7%、11.4%、10.0%、4.6%。PAE对14种药物的耐药率较高,分别为复方新诺明、庆大霉素、头孢噻肟、头孢吡肟、氨曲南、环丙沙星、左氧氟沙星盐,其耐药率达45%、84.9%。结论:铜绿假单胞菌的耐药性已十分严重,应引起临床医师的高度重视。

OBJECTIVE ：Toinvestigate the infection statues and drug-resistance of Pseudomonas （PAE）In nosocomial infections to provide the scientific according to the clinical application of the antibiotice.METHODS：PAE were cultured and idenyified according to the National Clinical Laboratory Operation Rules. The drugSensitivity testing was performed by K-B methods. RESULTS：Totally 219 strains of PAE were mainly isolatedFrom the intensive care unit（31 .1 %）, department of internal medicine（24.7%）, department of surgery（18.7%）And department of tumor（17.3%）. Most of the ABA strains were detected from sputum, pus and secretions,Urine chest ascites and blood, accounting for 31.1%, 24.7%, 18.7%and 17.3%, respectively. Drug resistanceRates of PAE were higher to 14 kinds of antibiotics were including SMZ/TMP, gentamycin, cefotaxime, Cefepime, aztreonam, ciprofloxacin, levofloxacin and so on, arriving at 45.2%-84.9%. CONCLUSlON：DrugResistance status of PAE is serious. Hospital should strengthen the monitoring, prevention and controlling of it.