TNFα-1031T/C基因多态性与轻度认知功能障碍的相关性

Relationship between Tumor Necrosis Factor-α-238A/G Gene Polymorphism and Mild Cognitive Impairment Patients

目的:探讨肿瘤坏死因子TNFα-1031T/C基因多态性与轻度认知功能障碍(MCI)的相关性。方法:选择MCI患者50例,非MCI正常人112例,应用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法检测TNFα-1031T/C的基因多态性。结果:TNFα-1031T/C等位基因的频率在MCI组与非MCI组无统计学差别(P<0.05)。结论:TNFα-1031T/C等位基因与MCI无关。

Objective:To investigate the relationship between tumor necrosis factor-α(TNF-α)- 1031 T/C gene polymorphism and mild cognitive impairment(MCI)in patients,and their correlative risk factors thereof.Methods:50 cases of MCI and 112 cases of normal contral were selected for this study.The polymorphism of the TNFα-1031 T/C was detected by PCR-restriction fragment length polymorphism(PCR-RFLP). Results:The frequency of TNFα-1031 T/C allele was no significantly difference between the group MCI and contral group(P>0.05).Conclusion: There is no significant relationship between TNFα-1031 T/C allele and MCI.