猪复合皮移植的实验研究

Experimental study about the grafting of composite skin on swine

目的 :为使复合皮移植的动物实验结果进一步接近临床 ,用小香猪作动物模型 ,探讨复合皮移植的术后效果和成活机制。方法 :实验分 3组 ,A组为移植异体普通乳猪真皮 +成年小香猪自体表皮皮片 ;B组为移植异体成年小香猪真皮 +成年小香猪自体表皮皮片 ;C组为移植成年小香猪自体表皮皮片。术后观察 3组皮片的存活质量及组织学变化。结果 :3组皮片早期成活情况均较好 ,A组和B组晚期收缩率及瘢痕程度均比C组低。A组和B组的组织学结构较完整 ,异体普通乳猪真皮的成活情况优于异体成年小香猪真皮。结论 :异体真皮的存在能改进复合皮移植的质量 。

Aim:Swine were used as animal models for composite skin to make their experimental results close to clinic, and to explore their survival mechanism and results after the operations. Methods:Three groups were designed:in group A, allogenic dermis of new borne swine and autologous epidermis grafts were transplanted; but in group B, the allogenic dermis of adult swine and autologous epidermis graft; in group C, only the autologous epidermis graft. After the operations, the grafts were observed and tissue was obtained for histological study. Results: The survival status in 3 groups were satisfied in early time. The contractive rate and scar forming in group A and group B were lower than those in group C. There was much integral histological structure in group A and group B than that in group C, and the survival status in allogenic dermis of new borne swine was better than that in allogenic dermis of adult swine. Conclusion:Allogenic dermis can improve the composite skin's quality, furthermore, the composite skin having allogenic dermis of sucking swine has the best result.