CD_(117)在急性非淋巴细胞性白血病细胞的表达与患者生存时间的关系

A study on the expression CD_(117) in acute nonlymphoid leukemia and its impacts on survial duration

目的 观察CD117在急性非淋巴细胞性白血病 (ANLL)细胞中的表达 ,评价其对白血病患者生存时间判断方面的价值。方法 采用流式细胞仪对 6 6例ANLL患者的白血病细胞进行分析。观察CD117阳性和阴性患者的预后 ,并做多因素分析。结果 6 6例ANLL患者中 ,41例表达CD117,CD117在ANLL患者中各亚型的表达差异无显著性 (P >0 .0 5 )。CD117阳性患者完全缓解 (CR)率低(43 9% ) ,CD117阴性患者CR率高 (72 0 % ) (P <0 .0 5 )。CD117阳性患者生存时间短 (196d) ,CD117阴性患者生存时间长 (30 2d) (Log Rank检验P =0 .0 0 12 )。将年龄、性别、WBC、缓解、复发、CD117阳性分别引入Cox模型和logistic回归进行多参数分析 ,结果显示CD117可能是影响ANLL患者预后的一个因素(P <0 .0 5 )。

Objective To explore the expression of CD 117 on blasts of ANLL and its impacts on survial duration of patients with ANLL. Methods Single color flow cytometry was performed to examine CD 117 expression in 66 patients with ANLL. Prognosis of a CD 117 positive and CD 117 negative group was observed and prognostic factors were analysed. Results Of the 66 patients with ANLL,41 had CD 117 expression. There was no correlation between CD 117 expression and FAB subtypes. A lower complete remission (CR) rate ( P <0.05) and shorter survival duration were found in the CD 117 positive patients with ANLL (Log Rank test P =0.001 2) than those in the CD 117 negative. CD 117 negative group had higher cumulative survival, lower cumulative hazard than CD 117 positive group .Multivariation analysis, including age, sex, WBC count, CD 117 expression, remission and relapse, demonstrated that the expression of CD 117 in ANLL patients may be an independent prognostic factor. Conclusion ANLL patients with positive CD 117 expression had a poor prognosis.