热休克蛋白与肝缺血再灌注损伤

HEAT SHOCK PROTEIN AND HEPATIC ISCHEMIA REPERFUSIOIN INJURY

目的 了解热休克蛋白在肝缺血再灌注损伤过程中所处的位置、作用及其相关机理。方法 通过复习文献对热休克蛋白在肝缺血再灌注中的作用加以综述。结果 热休克蛋白是细胞受应激原刺激后诱导产生的、有利于增强机体抵御恶劣环境的一组应激蛋白 ;肝缺血再灌注可诱导生成热休克蛋白 ,并使之随肝损伤的加重而增多 ,对肝缺血再灌注所致的损伤起到保护作用。结论 热休克蛋白具有保护缺血肝脏 ,减轻再灌注损害的作用 ,还可以作为监测指标 ,更好地估计肝损伤程度 。

Objective To study the effects of heat shock proteins (HSPs) in the course of hepatic ischemia reperfusion injury (HIRI), and analyze its mechanism. [WT5”HZ]Methods [WT5”BZ]The relationship between HSPs and HIRI was studied by reviewing literatures. [WT5”HZ]Results [WT5”BZ]HSPs was a kind of stress protein induced after cell was sitmulated by the stress. It could improve body′s tolerance to tough situation. Though hepatic ischemia reperfusion usually results in serious hepatic injury, at the same time it could induce can increase the production of HSPs that can protect liver from and lessen ischemia reperfusion injury. [WT5”HZ]Conclusion [WT5”BZ]HSPs can improve the tolerance to HIRI and lessen injury. In addition, HSPs is thought to be markers of HIRI, and can be used as a efficient indicator to test the level of hepatic injury and assess prognosis.