重组人脑钠素在心脏外科围手术期中的应用

Recombinant Human B-type Natriuretic Peptides in Cardiac Surgical Procedures

目的:探讨重组人脑钠素(recombinant human B-type natriuretic peptides,rhBNP)在心脏外科围手术期的应用价值。方法:对20例心脏外科手术患者在围手术期应用rhBNP(研究组),分别于治疗前和治疗后1～2周行彩色多普勒超声心动图及血液检查。以同期不应用rhBNP的20例心脏外科手术患者作为对照组。结果:研究组患者治疗后左室射血分数(LVEF)、左室缩短分数(FS)、心脏指数(CI)较治疗前显著升高,而血浆中N-端脑利钠肽前体(NT-proBNP)含量、血清肌钙蛋白肽T(cT-nT)、肌酸激酶同功酶(CK-MB)较治疗前显著降低。结论:rhBNP在心脏外科围手术期中的应用可以明显改善患者心脏功能,使其顺利渡过手术并减少术后并发症。

Objective： To evaluate the treatment effect of recombinant human B-type natriuretic peptides（rhBNP） in cardiac surgical procedures. Methods： Twenty patients undergoing cardiac surgery were administered rhBNP, and they under went Doppler echocardiography and laboratory test. The results were compared with those of 20 patients who didn＇t take rhBNP. Results： The left ventricular ejection fraction, fractional shortening and cardiac index increased after treatment with rhBNP, while NT-proBNP,cTnT and CK-MB were reduced after treatment with rhBNP. Conclusions： Application of rhBNP can im- prove heart function of the patients in cardiac surgical procedures.