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海洋抗肿瘤天然活性物质Apratoxin家族研究进展

Overview about the Research of Apratoxins Family-Anti-tumor Marine Natural Products
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摘要 Apratoxins家族是由海洋蓝藻菌中分离得到的一种次级代谢产物,通过抑制共翻译转运过程表现出强力细胞毒性活性,具有作为抑癌药物的开发潜力。近年来由于Apratoxins家族抑制肿瘤的高效活性,人们对它们的合成以及药理机制已经做了大量研究,本文主要对近年来Apratoxins家族的研究进展做一简要介绍。 Apratoxins are cytotoxic marine natural products isolated from cyanobacterium that had been prevented cotranslational translocation early in the secretory pathway and should be a potential anti-tumor drug. In recent years, lots of work has been carried out on their synthesis and pharmacological mechanism. A brief introduction on the research progress of Aparatoxins family was carried out.
作者 黄东成 吴洁 顾觉奋
机构地区 中国药科大学生命科学与技术学院
出处 《国外医药（抗生素分册）》 CAS 2012年第5期193-198,共6页 World Notes on Antibiotics
关键词 Apratoxins 海洋天然产物 抗癌 apratoxins marine natural products anti-tumor
分类号 R979.1 [医药卫生—药品]
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参考文献20

  • 1Luesch H, Yoshida WY, Moore RE, et al. Total Structure Determination of Apratoxin A, a Potent Novel Cytotoxin from the Marine Cyanobacterium Lyngbya majuscule [J]. Am. Chem. Soc’ 2001,123:5418.
  • 2Luesch H, Yoshida WY, Moore RE, et al. New Apratoxins of Marine Cyanobacterial Origin from Guam and Palau[J]. Bioorg Med Chem, 2002, 10: 1973.
  • 3Matthew S, Schupp PJ, Luesch H. et al. A cytotoxic peptolide from a guamanian collection of the marine cyanobacterium lyngbya bouillonii [J]. Nat Prod,2008, 71:1113.
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  • 7Liu JO, Ma D, Zou B,et al. Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of theirBiological activities[J]. Chem Eur J, 2006, 12:7615.
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国外医药（抗生素分册）
2012年 第5期

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