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单纯性及特殊情况时肝素诱导的血小板减少症治疗 被引量：2

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摘要 肝素诱导的血小板减少症（HIT）是肝素治疗的常见并发症，而HIT的并发症并非出血性疾病而是血栓形成。虽然近数年加强了对HIT的治疗研究，但有许多问题例如单纯性HIT（无血栓形成的HIT）如何处理以及急性HIT患者需行急诊心脏外科手术、急诊经皮冠状动脉介入治疗（PCI）等特殊情况如何治疗尚未完全解决。我们对单纯性及特殊情况时HIT的当今最佳治疗策略进行讨论。
作者 赵梦华 石建平 徐宝元
机构地区 邯郸市中心医院心内科
出处 《临床荟萃》 CAS 2012年第20期1833-1836,共4页 Clinical Focus
关键词 血小板减少症 肝素 治疗
分类号 R558.2 [医药卫生—血液循环系统疾病]
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参考文献22

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同被引文献38

  • 1季闽春,钱庆庆,杨耀芳.肝素诱导的血小板减少症的病因、诊断和治疗研究进展[J].中国临床药理学杂志,2007,23(6):461-465. 被引量：21
  • 2刘新,李爱.输血后紫癜[J].山东医药,2005,45(16):76-77. 被引量：2
  • 3赵彬,梅丹,李拥军,管珩.肝素诱导的血小板减少症[J].中国药师,2007,10(8):822-824. 被引量：12
  • 4Warkentin TE, Greinacher A, Koster A, et al. Treatment and prevention of heparin - induced thrombocytopenia: American Col- lege of Chest Physicians Evidence - Based Clinical Practice Guidelines ( 8th edition ) [ J ]. Chest, 2008, 133 ( 6 Suppl ) : 340S - 380S.
  • 5Lubenow N, Eichler P, Lietz T, et al. Lepirudin for prophylaxis of thrombosis in patients with acute isolated heparin - induced thrombocytopenia: an analysis of 3 prospective studies[ J ]. Blood, 2004, 104(10) : 3072 -3077.
  • 6Lewis BE, WaUis DE, Leya F, et al. Argatroban anticoagulation in patients with heparin - induced thrombocytopenia [ J ]. Arch Intern Med, 2003, 163 (15) : 1849 - 1856.
  • 7Kiser TH, Jung R, MacLaren R, et al. Evaluation of diagnostic tests and argatroban or lepirudin therapy in patients with suspected heparin -induced thrombocytopenia[ J]. Pharmacotherapy, 2005, 25(12) : 1736-1745.
  • 8Smythe MA, Stephens JL, Koerber JM, et al. A comparison of lepirudin and argatroban outcomes [ J ]. Clin Appl Thromb Hem- ost, 2005, 11(4) : 371 -374.
  • 9Tardy B, Lecompte T, Boelhen, et al. Predictive factors for thrombosis and major bleeding in an observational study in 181patients with heparininduced thrembocytopenia treated with lepiru- din[J]. Blood, 2006, 108(5) : 1492 -1496.
  • 10Hursting M J, Softer J. Reducing harm associated with anticoagula- tion : practical considerations of argatroban therapy in heparin - in- duced thrombocytopenia[ J]. Drug Saf, 2009, 32 (3) : 203 - 218.

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临床荟萃
2012年 第20期

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